In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17β-estradiol.1 In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16α-hydroxyestrone (16α-OHE1). Both 16α-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16α-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative.2 As such, an increased ratio 2-OHE:16α-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women.3 Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events.4 Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.5 It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.6
|Each Vegetarian Capsule Contains:|
|Calcium D-Glucarate (d-Glucaric Acid Calcium Salt)||75 mg|
|Indole-3-Carbinol (3-Hydroxymethylindole)||75 mg|
|Green Tea Extract (Camellia sinensis) (leaf) (80% Catechins, 45% EGCG*, <1% Caffeine)||50 mg|
|Tomato Extract (Lycopersicon esculentum) (fruit) (5% Lycopene)||50 mg|
|Broccoli Powder (Brassica oleracea var. italica) (aerial) (0.36% Sulforaphane)||27.5 mg|
|DIM (3,3’-Diindolylmethane)||25 mg|
|Turmeric Extract (Curcuma longa) (rhizome) (95% Curcuminoids)||25 mg|
|Milk Thistle Extract (Silybum marianum) (seed) (50–60% Silymarin)||25 mg|
|Rosemary 6:1 Extract (Rosmarinus officinalis) (leaf)||12.5 mg|
Directions for Use: 3 capsules once per day with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.
Contains no: artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.